There are 2 main sources of cancer
- inherited cancer
- Sporadic cancer
These are some cancers that are highly inherited, these are from genes which highly predispose you to cancer
Some of these are talked about in this lecture
Some inherited cancer syndromes
Familial breast ovarian cancer
Lynch syndrome
Familial adenoamatous polyposis
Hereditary diffuse gastric cancer
Hallmarks of inherited cancer
- High incidence in family groups
- predominance of particular cancer types
- Early age of onset
- Increased risk of multifocal/bilateral disease
Summary of inherited cancer
Highly penetrant cancer syndrome are caused by germline mutations in tumour suppressor genes Usually dominantly inherited relatively rare but high impacy with correct management there is low mortality rate
Cancer genetic and management of advanced cancer
Our current management is
- population based controls
- recieve treatment that is best for the average population
- Good approach but only if you are average Emerging treatments are
- personalised treatment
- Receive best treatment for your specific type of cancer
Genetic methods in personalised treatment
- Prognosis/risk of recurrence
- Drug target identification
- Markers of treatment response and relapse
Prognosis/risk of recurrence
Mammaprint
Oncotype Dx breast cancer recurrence score
Drug target identification
He touches a bit on receptor amplification and antibody drug conjugates
we can sequence tumour dna and see what types of mutations they have, and then see what drugs will be effecting