Molecular biology 4
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Status: S1LectNotes Time: 2025-03-15 Tags: lecturenotes Links:
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Take home:
Things to note:
Rambles: gene networks
gene networks describe how the activity of one single gene can influence the activity of other genes
makes regulating gene expression very complex
also phenotype = genetics + environment
complex diseases have many factors and components affecting them buth multible genetic factors as well as multiple environmental factors
lifestyle and environmental factors affect gene transcription
food
- folate
- EGCG
- Selenium physical activity tobacco smoke intrauterine life maternal diet alcohol pollutants aging stress
cancer hyper methelation of tumour suppressor hypo methylation of oncogenes
insulin like growth factor receotir
high insulin can increase development of cancer
autoimmunity
epigenetics can predispose someone to mental disorders and or addictions etc
drugs can bind and chemically modify dna
diabetes
physical activity lipogeneis genes increase expression of tumour suppressor genes decreased expression of oncogenes
dna methylation improves miRNA expression patterns in leukocytes
GO EXERCISE
Diet folate and b vitamins
friuts and veges are particularly good at activating dna repair genes
folate is great
chemical and toxins can also affect your epigenetic genotype
\infection can also modify dna
maternal influences
your grandparents affected you
presicion medicine once you learn about the epigenome you can better help them by taregeting drugs
epigenetic therapy