microbiome
the microbiome is colocise by a comples community microbes they colonise body site exposed to the envirnment. There are discrete concepts of microbiota and microbiome. massive amount of microbomes
What is in your gut? complex diverse biome. colonisation begins soon after birth. compostion is relatively stable though life and changes can occur due to diet and treatments.
gut microbiome
mostly anaerobic microbes obligate anaerobes lactobacillus bifidovacterium commensal and used in probiotsc
clostridium and cateroides
- oppertunistics faculatative anaeroves enterobacteralse enterococci pseudomonal streptococcus stapylocuccuc
what does it do? muatalistic relationship important for oveerall health and development many functions immune colinisation rsistance metabolism of drugs bilidrubin breakdown vitamins and amino acids immunological tolarance normal gut function and energy alcage
make short chain fatty acids
whait if it goes wrong? dysbiosis: changes in gut microbioe assocaited with disease
iption 1 microbiome causes disease
option 2 dysbiosis is caused by diseae
option 3 geneticallsu susceptible host disease inflamamtion microbiome changes inflammation changes
dysbioisis is linkd to many condiditon and
occational opportunistic infections anarobic infection coss boewl epitheliam forgoration of bowel - bacteramia poly microbial abcess fo abdominal organs periotnitis faculatative anaerobes use up o2 and allow obligate anatobes to grow
tratment antimicrobials iwth actibvity against oblifate anatobles metronidazole etc
gas gangrebne clostridium perfringens
tocxins necrosis of soft tissue and msucel gas production follow traua and GI curget repidly progenssive traetmt iv penicillina nd clindamycin
necrotising enterocolitis perterm infants preterminfants and associated with dysbiosis
7% premature infants
common cause of nicu admission
hekico bacterpylori