Histology 1 Bone, Cartilage and joints### Links:
Time: 2025-04-15
Objectives:
- Introduction into connective tissue
- introductions to cartilage
- Types of cartilage
Glossary
Classification of connective tissue
| Irregular CT | Examples | Regular CT | Examples |
|---|---|---|---|
| Loose fibrous connective tissue | - submucosa of digestive tract - internal organs - lamina propria | Loose fibrous connective tissue | |
| Dense irregular CT | - dermis - adventitia of BV - capsules of large organs | Dense fibrous connective tissue | |
| Adipose tissue | - subcutaneous tissue - breast and bone marrow | fascia and aponeurosis ligaments tendons |
Connective tissue somposition
Connective tissue contains cells and ECM ecm is fibres + ground substance
- ground substance is glycosaminoglycans proteoglycans, and hyaluron
- fibres are elastin and collagen
Cells of CT
Resident cells fibroblasts
- make ECM
- spindle shaped
- most numerous
- adhered to fibres lipocytes
- oval/ spherical shape
- single or in a froup
- centre holds fat
- peripheral rom of cytoplasm with nucleus mesenchymal stem cells migrant cells mast cells mainly seen in loose CT round central nucleus prominent vesicles and golgu histamin and heparin and such secretion in response to trauma/antigen
macrophages lymphocytes
Components of Connective tissue
Collagen
structural protein with lots of strength usually white and runs paralell 4 types of collagen
- dermis vone tendon ligaments etc (most common)
- cartilage
- dermis
- basal lamina
Elastin
Less common than collagen fibres can branch out stretch and recoil
Ground substance
Cartilage
Cartilage is load bearing CT covered by perichondium (except in articular surfaces)