AntiCCP anticyclic citrullated protein antibodies citrullated proteins are often found in articular surfaces in the body RF rheumatoid factor autoreactive protein which recognises the Fd domain of IgG antibodies ANA Antinuclear antibody CRP C Reactive protein ESR erythrocyte sedimentation rate anticarbamylated peptide antibodies
seropostive RA and seronegative RA
seropostive RA has the presence of key markers such as RhF and AntiCCP antibody
it is suggested that seropositive may have a higher level of heritability or genetic origin
pathogenesis Anti Citrullated Protein Antibodies recognise citrullated residual on many proteins in the body, causing an immune response.
tissue origin of such reactivity is uncertain but evidence points to mucosal sites potentially the lungs as this could explain the relationship between smoking and RA.
over time ACPAs increase in concentration and diversity
the effects of ACPAs may be direct, by activating macrophages, or by osteoclast activation or possibly membrane cit-vitmentin binding.
often acpas do not become seronegative, unlike RF
clonal t cell expansions have o
multiple stages of Ra have different markers which can tell us about it
triggers can include proteus, EBV, and ecoli which can trigger