Parkinsons is a disease characterised by slow movement, resting tremors, rigid muscles, and balance issues. It is often age related and is associated with deterioration of the caudate nucleus of the basal ganglia.
Clinical aspects of parkinsons
Molecular basis of parkinsons.
Parkinsons disease is characterised by decline and eventual death of substantia nigra in the basal nuclei, which leads to decreased dopaminergic signalling in the striatum.
[[Cerebrum#Basal ganglia#Function|Basal ganglias functions]]
This leads to underactivity of the direct pathway and overactivity of the indirect pathway, which in turn leads to excessive inhibitory output to the thalamus.
This leads to the symptoms of parkinsons.
Treatment
Treatment of parkinsons is with Anti-parkinsonians. There is no treatment which indefinitely prolongs this and in fact it can also cause schizophrenic like symptoms due to too much dopamine being in the nucleus accumbens