Histology 1 Bone, Cartilage and joints# Links:
Time: 2025-04-15
Objectives:
- Introduction into connective tissue
- introductions to cartilage
- Types of cartilage
Glossary
Classification of connective tissue
| Irregular CT | Examples | Regular CT | Examples |
|---|---|---|---|
| Loose fibrous connective tissue | - submucosa of digestive tract - internal organs - lamina propria | Loose fibrous connective tissue | |
| Dense irregular CT | - dermis - adventitia of BV - capsules of large organs | Dense fibrous connective tissue | |
| Adipose tissue | - subcutaneous tissue - breast and bone marrow | fascia and aponeurosis ligaments tendons |
Connective tissue somposition
Connective tissue contains cells and ECM
ecm is fibres + ground substance
- ground substance is glycosaminoglycans proteoglycans, and hyaluron
- fibres are elastin and collagen
Cells of CT
Resident cells
fibroblasts
- make ECM
- spindle shaped
- most numerous
- adhered to fibres
lipocytes - oval/ spherical shape
- single or in a froup
- centre holds fat
- peripheral rom of cytoplasm with nucleus
mesenchymal stem cells
migrant cells
mast cells
mainly seen in loose CT
round
central nucleus
prominent vesicles and golgu
histamin and heparin and such
secretion in response to trauma/antigen
macrophages
lymphocytes
Components of Connective tissue
Collagen
structural protein with lots of strength
usually white and runs paralell
4 types of collagen
- dermis vone tendon ligaments etc (most common)
- cartilage
- dermis
- basal lamina
Elastin
Less common than collagen
fibres can branch out
stretch and recoil
Ground substance
Cartilage
Cartilage is load bearing CT
covered by perichondium (except in articular surfaces)