EBP: Concept Checklist
Concepts covered across the module lectures, grouped by lecture. Tick each once you can explain it from memory.
L1 EBP (23 Feb) L1 EBP EBP
- Pathophysiology and features of PNH, and eculizumab’s mechanism, benefits and infection risk
- Interpreting GRADE recommendation strength and evidence quality (e.g. Grade 1B)
- PHARMAC and PTAC decision criteria for funding medicines
- The five steps of the EBP cycle
- Formulating a PICOT question
- CEBM levels of evidence by question type
- The pyramid of pre-appraised evidence and matching Otago library resources to each level
- Limitations of pre-appraised summaries, and when to search for primary evidence
- Structure and yield of a systematic database search
- Appraising the Hillmen 2006 eculizumab RCT: PICOT, primary outcomes, and why it could not answer the thrombosis question
- Assessing risk of bias with RAMBOMAN and the Cochrane RoB 2 tool
- How PHARMAC used trial, natural history and observational evidence, and the tension between individual access and population resources
L2 What information do you need (21 Aug) L2 EBP What information do you need
- Translate clinical uncertainty into an answerable question using PICOT/PECOT
- Where to look for evidence first: guidelines, systematic reviews and meta-analyses before individual studies
- Hierarchy of evidence by study design, and why the ranking depends on the question and study quality
- OCEBM 2011 levels of evidence for prevalence, diagnosis, prognosis, treatment benefit, common and rare harms, and screening
- Reasons to grade a level of evidence up or down
- Evidence-based practice in clinical settings (evidence, expertise, patient values) vs public health (four domains)
- Pertussis: disease, NZ epidemiology, immunisation schedule and timing of the antenatal booster
- Evidence on safety and effectiveness of pertussis vaccination in pregnancy, and contrasting it with misinformation
- Historical evidence on blood pressure: observational studies, early RCTs, Prospective Studies Collaboration meta-analysis
- SPRINT trial: PECOT, main results, adverse events and interpretation
- Road speed limits: evidence on impact speed and pedestrian fatality, co-benefits, and how organisational context can override research evidence