Clozapine is an atypical antipsychotic.
Clozapine is an antagonist at serotonin 5-HT2A receptors and the D4 receptors. It can improve the negative symptoms of schizophrenia and has a lower risk of parkinsons like symptoms. High doses can have similar side effects to typical anti-psychotics.
Side effects
Clozapine is not a first line treatment due to side effects. It has a 3.8% risk fo neutropaenia and agranulocytosis (which is fatal in 0.01% of cases.)
Clozapine is also an adrengergic α1 receptors which means decrease in blood pressure. It can cause weight gain, constipation and sedation.
Clozapine has the highest efficacy of antipsychotic drugs.