For drug profile see link ^
Therapeutic uses
Primary and renovascular hypertension
-
Effects on cardiovascular system
Produces arterial and venous dilatione
reduces arterial and venous pressures -
Effects on kidney
Promotes natriuresis and diuresis
Decreases Blood volume (lowers BP)
Effective in hyper-reninemic hypertension but still reduces BP in patients with low to normal renin levels (maybe due to bradykinin)
Additionally different ethnicities produce different levels on renin and will respond differently
Inhibition of Ang II production also crucial for proinflammatory and profibrotic effects of HTN
Chronic heart failure
reduced afterload
reduced preload
reduced sympathetic activation
and renal disease diabetes post MI stroke prophylaxis etc (MED3)
Adverse effects
- bradykinin related ADRs
- persistent dry cough and rarely angioedema
- initial hypotension
- rash
- disturbed sense of taste
- foetal abnormalites
- can lead to renal issues
contraindicated in angioedema can cause swelling