Anti-epileptics
This is often a first line antiepileptic, and has an unproven MOA, it may inhibit synaptic synaptic vesicle protein 2A which has important function in regulating number of vesicles ready to release NTs. Inhibition of SV2A acts to decrease release of NTs and acts to decrease signalling.
It has limited drug interactions
This is especially used for focal and GTC seizures. It may worsen myoclonic seizures.
Cautions
Use in caution in patients with mood disorders and kidney dysfunction.
Side effects
- Dizziness
- Headache
- Irritability
- Loss of strength and energy
- Mood and behaviour changes
- Sleepiness