MoA
Valproate acts to inhibit GABA transaminase, therefore leading to increase synaptic concentrations of GABA. it is also used to treat mania, in bipolar disease.
It is used to treat focal, GTC, absence, and myoclonic seizures.
Side effects
- Feeling tires
- Dizziness
- Upset stomach
- Vomiting
- Tremor
- Hair loss
- Weight gain
- Changes in behavior
Interactions
Carbepenem antibiotics increase excretion of valproate, and will need to be accounted for as lower blood concentration of valproate can lead to increased risk of seizure.
Valproate inhibits the metabolism of lamotrigine (sometimes used as a antiepileptic). Therefore increasing effect of antiseizure medication, (and adverse effects) when prescribed together.