Doxazosin (2nd to 3rd line treatment of HTN)
selective vascular a1 blocker
reduce BP in mild to moderate HTN but not usually suitable as monotherapy
vasodilator: a1-mediated sympathetic tone
relaxes smooth muyscel of both resistance vessels and veins
- reduced peripheral vascular resistance and increases venous capacitance value; less reflex tachycardia then nonselective a blockers celectivity at a1 meands less likely to block a1
uretheric hyperplasia and benign prostatic hyperplasia
good LDL/HDL profile
side effects
postural hypotension
depression
drowsiness
nasal stuffines
diarrhoea
less ejac
urinary incontenenct